Health
Author`s name Lisa Karpova

New genetically modified bacteria fights infections

New genetically modified bacteria fights infections. 45164.jpegModified E. coli was able to find and kill other bacteria that cause infections in hospitalized patients

by Maria Fernanda Ziegler, iG


Researchers in Singapore have succeeded in creating a laboratory bacterium, Escherichia coli, genetically engineered to combat hospital infections. The new bacterium was built from tools of synthetic biology. It is able to perceive and kill Pseudomonas aeruginosa, another bacterium responsible for pulmonary and gastrointestinal infections in hospitalized patients. In the experiment conducted in the laboratory, the E. Coli killed a culture of Pseudomonas aeruginosa in just 18 hours.

The study represents a step towards healing of infections caused by P. aeruginosa. It will still need to be tested on animals and humans. "It will still take a few more years so that the modified bacteria can develop and be used to treat infections in real patients. The next step is to test on animals," said IG's Matthew Wook Chang, Nanyang Technological University, Singapore, and author of the study.

The logic of the study was to create a "spy" for the messages given by the bacterium P. aeruginosa. In the war of bacteria, modified E. coli fared better. And researchers have only managed it by making an analysis of the ways "messages" go between the bacteria of the colony.

"The genetic modifications were made by inserting pieces of DNA that encode the proteins used in the communication system, which contains important information such as control instructions, for example, those that decide how and when each part of the system is activated," said IG's Andrew Hufton, editor of the journal Molecular Systems Biology, which published the study on Tuesday (16th).

Tactical War

Many bacteria have a natural system of communication among themselves, as is the case of P. aeruginosa. It releases other molecules that detect bacteria like it, thus allowing the colony to make more efficient "decisions" to attack the body.

But this war is not so simple. While there is a system of cooperation, the bacteria are also often unfriendly to one another. The P. aeruginosa often releases toxins that kill other bacteria in the colony. "Once again, the researchers took the gene responsible for the biological role of P. aeruginosa, and introduced it into the DNA of E.coli," said Hufton.

It is noteworthy that the study does not represent a cure of infections caused by P. aeruginosa, because the study was done only in laboratory bacterial cultures. Still, it shows that in the future, the modified E. coli may be a new weapon against the disease.

The researchers showed that the modified E.coli killed P. aeruginosa, with a reduction of 99% of viable cells, and it inhibited the formation of about 90% of biofilm formation (a type of bacterial growth that can be very difficult to treat, when it is found in an animal). For researchers, the new bacterium may be a new way to fight against P. aeruginosa, a bacterium that is becoming increasingly resistant to drugs.

 

Translated from the Portuguese version by:

Lisa Karpova

Pravda.Ru

The discovery of the submarine has unveiled a few "inconsistencies." For example, how can one explain the fact that the sub was found where it needed to be searched for from the start?

Argentina hides the truth about the death of San Juan submarine
Comments
Russia to ban capture of killer whales and belugas in 2019
North Korea destroys security points in demilitarised zone
Russia to ban capture of killer whales and belugas in 2019
Third Rome and geopolitics of Orthodox schism
Five years after Maidan revolution, Ukraine remains one of Europe's most corrupt states
The Amazon and the New Conquistadores
Brexit: The UK's misunderstanding of Democracy
The Amazon and the New Conquistadores
The Amazon and the New Conquistadores
Kuril Islands dispute between Russia and Japan: The impossible is impossible
Kuril Islands dispute between Russia and Japan: The impossible is impossible
Kuril Islands dispute between Russia and Japan: The impossible is impossible
Russia to raise sunken floating dock
Unemployment in Russia hits record high of 15 percent
Third Rome and geopolitics of Orthodox schism
Brexit: The UK's misunderstanding of Democracy
Why Trump tries to re-industrialize America
Why Trump tries to re-industrialize America
MP suggests replacing Lenin's mummy with rubber figure
Russian Navy admiral says Russia will torpedo US warships, if need be
The horror story called Brazil: Murder and destruction