Murtaugh, who joined SAIC in June 2006, said he had "accepted an offer from Chrysler Corp. that I think will be a tremendous opportunity for me. At this stage of my career, it is an offer I just cannot turn down."
"This has been a very difficult decision for me," Murtaugh said in a statement released by SAIC.
SAIC applauded Murtaugh's contribution to the Shanghai-based automaker's efforts to build up its own-brand business after nearly a decade of working with GM.
Murtaugh "contributed his rich experience in the auto industry and demonstrated solid capabilities as a professional manager," SAIC said in a separate statement.
Murtaugh did not say what post he would take up at Chrysler, which recently announced a deal with China's biggest independent car company, Chery Automobile Co., to jointly produce and export cars to Western Europe and the United States within 2 1/2 years.
It isn't the first time Murtaugh has made an unexpected move.
Widely credited with helping GM establish a leading presence in the increasingly competitive Chinese market, Murtaugh abruptly left the Detroit-based automaker in 2005 after nearly five years with GM's China Group, citing "personal reasons."
He had spent 32 years with GM, where he played a key role in the launch of Shanghai GM, the company's biggest mainland venture.
Staff at GM's Shanghai office said they had no comment on Murtaugh's departure for Chrysler.
World's most powerful nuclear submarines, Arkhangelsk and Severstal, are to be dismantled after 2020 - their further exploitation is unprofitable
The United States' Head of Diplomacy, or Secretary of State, is an anachronistic, incompetent, meddling, intrusive, insolent and arrogant, rude individual, a brash, foul-mouthed upstart, a conceited, self-important guttersnipe and an insult to the international community, as fit for the job as a pedophile janitor in a grade school.
Pentagon officials said that Russia has developed a very powerful weapon, which Western specialists have already dubbed as the "doomsday weapon"