People were killed, but state police did not immediately know how many.
A tanker truck may have spilled fuel and a tractor-trailer jackknifed and landed on its side during the 10:20 a.m. crash on Interstate 95, state police said.
"It's a significant accident," said Lt. J. Paul Vance, a state police spokesman.
Transportation officials said the accident would take seven to eight hours to clean up, snarling traffic on part of the key interstate highway in the Northeast corridor.
Firefighters were spraying foam as a precaution in a fuel spill, and state environmental officials were headed to the site.
The co-author of this disaster is the Dutch government, which did not find either strength or desire to save the lives of its citizens who were flying on that plane. The Dutch authorities did not demand Ukraine to comply with international aviation regulations
On the second day of the St. Petersburg International Economic Forum, a plenary meeting was held, in which Russian President Vladimir Putin, French President Emmanuel Macron, Japanese Prime Minister Shinzo Abe, Chinese Vice President Wang Qishan and IMF head Christine Lagarde took part