Click here to see more photos of the fire
The blaze broke out shortly after noon (1206GMT) in an industrial area in Stratford, authorities said. The fire is within the construction site for the 2012 Summer Olympics, the British Broadcasting Corp. reported.
About 75 firefighters from 15 fire engines were fighting the blaze, the London Fire Brigade said.
Extensive redevelopment is taking place in the area, about 9 kilometers (5.5 miles) east of central London.
Police said there was nothing to suggest a suspicious cause.
"We only know it's a fire," a Metropolitan Police spokeswoman said. "There's nothing to suggest anything else at the moment."
There were no reports of injuries. One railway line was closed because of smoke, Network Rail said.
Putin's official spokesman Dmitry Peskov commented on remarks in the US media about failures in launching nuclear-capable missiles in Russia
The Buk system that shot down MH17 belonged to the 53rd SAM missile brigade of the Russian Ministry of Defense, investigators say after looking at a few pictures on the net
It has long been understood that the West has been trying to subject Russian borders to total control. We have not seen such activity even during the Cold War