Source Pravda.Ru

Surgeons in first partial face transplant did not trying normal procedures first

Doctors who gave a French woman the world's first partial face transplant did not try normal reconstructive surgery first, raising questions about whether the operation was medically ethical, a surgeon familiar with the case said today. Dr. Laurent Lantieri also said he was concerned the patient may not be fit psychologically for the operation and its demands. However, the head of France's organ procurement agency disputed that notion, saying the patient had been thoroughly evaluated.

The 38-year-old woman, whose identity has not been disclosed, had surgery Sunday to replace her nose, lips and chin in Amiens, northern France. The donor was a brain-dead patient whose family gave consent. Although the woman was mauled by a dog in May, surgeons immediately sought a transplant donor without trying to repair her face through conventional surgical methods, said Lantieri, a reconstructive surgeon.

Lantieri, who works at Henri Mondor Hospital in Paris, was an adviser to the National Consultative Ethics Committee, which sets voluntary guidelines for medical procedures in France. The panel previously objected to full face transplants, but said partial ones could be considered under strict circumstances, which included first trying normal surgery.

However, Carine Camby, director general of the agency under the French Health Ministry that coordinates organ procurement, said her agency approved the transplant after long consultations with other French medical authorities. She said normal reconstructive surgery could not have been used in this case.

Camby also said the patient "received many psychiatric examinations. The psychiatrists decided that she understood the surgery and that she accepted all of the consequences, including the risk of rejection and of failure, the risk of immune suppression treatments and the need to take them for life. All of these points were discussed at length with her."

Lantieri said a surgeon in Lille who had seen the woman's medical record was concerned about her psychological suitability to endure the operation and adhere to the complex drugs needed lifelong to ensure the operation's success.

The operation was done Sunday by groundbreaking transplant surgeon Dr. Jean-Michel Dubernard and Dr. Bernard Devauchelle. Dubernard led teams that performed a hand transplant in 1998 and the world's first double forearm transplant in January 2000. The hand transplant recipient later had it amputated. Doctors said he failed to take the required drugs and his body rejected the limb.

Lantieri said he was fearful that this transplant could turn out like that first hand transplant if the patient is psychologically unstable. Dubernard did not return a phone call seeking comment. The face transplant patient was to have a second experimental treatment today _ an infusion of the donor's bone marrow _ to try to prevent rejection of the new tissue.

"Maybe Jean-Michel Dubernard is revolutionizing the concept of transplantation," Lantieri said, but added that the patient now was being subjected to two untested treatments. Lantieri, who developed his own plans to attempt a partial face transplant, said members of Dubernard's team contacted him last spring, seeking details of his protocol.

He saw a photograph of the victim, whose injury was unusually severe. He also said that a surgeon in Lille, France, where the transplant donor lived, had reviewed the woman's record and told him he was concerned about the circumstances of her injury. It involved one or two dogs, Lantieri said.

In the United States, surgeons and psychologists at two medical centers that hope to offer face transplants _ the Cleveland Clinic and the University of Louisville _ declined to comment Thursday on the French case. Privately, several people involved in those plans said they feared that if the French procedure does not go well or the ethics of it become an issue, it might damage confidence in their ability to do such an operation under better circumstances with carefully selected patients.

In an interview at the Cleveland Clinic in July, surgeon Dr. Maria Siemionow stressed the several years she had spent developing procedures and how carefully her team now is working to select potential candidates for the operation.

Another surgeon familiar with the French case sounded more optimistic despite the woman's horrific injuries, which he said were caused by her own dog. Owen said he supervised the French surgeons as they practiced for the procedure. He said the woman will look more like herself than the donor, who he said was a woman, the AP reported.

A.M.

On December 10, 1948 the Universal Declaration of Human Rights was adopted by the United Nations General Assembly, its thirty articles enshrining basic and fundamental rights guaranteeing dignity of the human person and equality for all, regardless of race, color, creed or gender. A pipe dream?

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