Source Pravda.Ru

Scientists unveil new facts about HIV

University of California-San Francisco scientists have discovered how the human immunodeficiency virus can be kept dormant and hidden in immune cells.

The findings suggest new potential therapeutic approaches for viral eradication from infected patients, according to lead author Dr. Warner Greene, professor of medicine, microbiology and immunology.

Current combined antiviral therapies that target essential components of replicating HIV fail to achieve eradication of the virus from infected patients. That, said Greene, is due in part to the presence of rare cells harboring silent copies of the HIV virus - a dangerous reservoir of literally "invisible" viruses that might potentially reactivate and seed a new infection.

Greene and colleagues report significant progress toward the understanding of the molecular mechanisms responsible for maintenance of HIV latency.

Specifically, the team demonstrated viral gene expression is actively repressed by the inhibitory NF-kappaB p50 protein. That inhibition is mediated by an enzyme called HDAC1, which is capable of shutting down gene expression in its vicinity, UPI reports.

V.Y.

Representatives of the North Korean administration issued a statement saying that the United States and its allies have lost the "political and military confrontation" to the DPRK

North Korea declares victory over USA

In recent years, genetics has become a cutting-edge science, not only in the professional field of biology, but also because of the enormous social reach of its discoveries and approaches. Not in vain, practically every day the press offers us the discovery of a new gene, a new hereditary determinant directly involved in the manifestation of diseases or physical characteristics.

The Myth of the Gene: Genetics, Epigenetics and the Organism-Environment Loop
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