Source Pravda.Ru

Nexavar trial ended by Bayer and Onyx

Bayer HealthCare Pharmaceuticals Inc., a German chemical and pharmaceutical company, and Onyx Pharmaceuticals Inc., a pharmaceutical research company, specializing in cancer treatments, stopped the trial of Nexavar.

Nexavar is a drug approved for the treatment of advanced renal cell carcinoma (primary kidney cancer). It has also received "Fast Track" designation by the FDA for the treatment of advanced hepatocellular carcinoma (primary liver cancer), and has since performed well in Phase III trials.

The reason for this sudden stop is that the study would not meet its primary goal of improving overall survival.

The drug was approved by the U.S. Food and Drug Administration (FDA) on December 20, 2005 and received a E.U. marketing authorisation on July 19, 2006.

A New England Journal of Medicine article published in January 2007 showed compared with placebo, treatment with Nexavar prolongs progression-free survival in patients with advanced clear-cell renal-cell carcinoma in whom previous therapy has failed; the median progression-free survival was 5.5 months in the Nexavar group and 2.8 months in the placebo group (hazard ratio for disease progression in the Nexavar group, 0.44; 95% confidence interval [CI], 0.35 to 0.55; P<0.01). The first interim analysis of overall survival in May 2005 showed that Nexavar reduced the risk of death, as compared with placebo (hazard ratio, 0.72; 95% CI, 0.54 to 0.94; P=0.02), although this benefit was not statistically significant according to the O'Brien–Fleming threshold. Partial responses were reported as the best response in 10% of patients receiving Nexavar and in 2% of those receiving placebo (P<0.001).

At ASCO 2007, results from the SHARP trial were presented, which showed efficacy of Nexavar in hepatocellular carcinoma. The primary endpoint was overall survival, which showed a 44% improvement in patients who received Nexavar compared to placebo (hazard ratio 0.69; 95% CI, 0.55 to 0.87; p=0.0001). Both median survival and time to progression showed 3-month improvements.

Photo: raquelbilliones.healtheva.com

He announced his intention to create a news service called "Pravda," which means "truth" in Russian. Well, we are Pravda. The Pravda.Ru website has been working professionally in Russia since 1999

Elon Musk wants Pravda, but we already have it

The co-author of this disaster is the Dutch government, which did not find either strength or desire to save the lives of its citizens who were flying on that plane. The Dutch authorities did not demand Ukraine to comply with international aviation regulations

Blame MH17 on Russia: International investigation turns into demonic circus

On the second day of the St. Petersburg International Economic Forum, a plenary meeting was held, in which Russian President Vladimir Putin, French President Emmanuel Macron, Japanese Prime Minister Shinzo Abe, Chinese Vice President Wang Qishan and IMF head Christine Lagarde took part

World leaders unite with Russia at St. Petersburg International Economic Forum
Comments
USA wants China to become backward, third world state again
Elon Musk and a Truth called Pravda
Science Has Once Again Declared: ‘We Were Created’
World leaders unite with Russia at St. Petersburg International Economic Forum
What would you do if you were Kim Jong-un?
There's only one man who can help Russia and the West bury the hatchet
World leaders unite with Russia at St. Petersburg International Economic Forum
World leaders unite with Russia at St. Petersburg International Economic Forum
World leaders unite with Russia at St. Petersburg International Economic Forum
The Netherlands and Australia officially accuse Russia of downing MH17 over Donbass
The Netherlands and Australia officially accuse Russia of downing MH17 over Donbass
The Netherlands and Australia officially accuse Russia of downing MH17 over Donbass
How low will America go?
German expert explains why European Union and Russia develop ties speedily
How low will America go?
Elon Musk wants Pravda, but we already have it
Blame MH17 on Russia: International investigation turns into demonic circus
How low will America go?
How low will America go?
Skripals fall under heavy British pressure
Skripals fall under heavy British pressure