Source Pravda.Ru

ACE inhibitor can substitute ARB in treatment of heart failure

According to a new study, ACE inhibitor ramipril (Altace) proved to be as effective as its more expensive competitor ARB telmisartan (Micardis).

Both drugs are used in treatment of hypertension and congestive heart failure, but have different ways of acting.

ACE inhibitor lower the production of angiotensin II, therefore relaxing arterial muscles while at the same time enlarging the arteries, allowing the heart to pump blood more easily, and increasing blood flow due to more blood being pumped into and through larger passageways.

Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a reduction in arterial blood pressure.

The study is based on a number of experiments conducted among people with coronary artery disease or diabetes that resulted in no major differences between those treated with different drugs.

The finding is very valuable in the sense that it provides a substitute for an ACE inhibitor in a patient who cannot tolerate it and reduces the cost of medical care.

Comments
Boris Yeltsin tried to escape to US Embassy as USSR was falling apart
Putin sets Merkel against Trump. She doesn't mind
Boris Yeltsin tried to escape to US Embassy as USSR was falling apart
Boris Yeltsin tried to escape to US Embassy as USSR was falling apart
Boris Yeltsin tried to escape to US Embassy as USSR was falling apart
Putin sets Merkel against Trump. She doesn't mind
Putin sets Merkel against Trump. She doesn't mind
Ukraine dreams of what it can do to Crimea after winning war with Russia
US-Russian confrontation: War is peace, freedom is slavery
Default more likely to hit American, rather than Russian economy
Russia refuses to build helicopter carriers, but considers aircraft carriers
Pilot shares his impressions after flying Su-57 fifth-generation fighter
Turkey desperately tries to rescue its national currency as it falls to all-time lows
Boris Yeltsin tried to escape to US Embassy as USSR was falling apart
Terrorists attack police officers in Chechnya in a series of poorly prepared acts
Russia Must Die - The Deep State has Spoken
Oil prices may fall as USA saves record oil reserves
Putin sets Merkel against Trump. She doesn't mind
US-Russian confrontation: War is peace, freedom is slavery
Boris Yeltsin tried to escape to US Embassy as USSR was falling apart
Israel makes final warning to Iran