The couple wed Monday night, publicist Kelly Bush confirmed.
Maguire, 32, and Meyer have been together since 2003. The couple got engaged last year and have a daughter, Ruby, who was born in November.
Meyer is the daughter of Ron Meyer, president and chief operating officer of Universal Studios.
Maguire, best known for the "Spider-Man" series, also has starred in such films as "Seabiscuit" and "Wonder Boys."