Source Pravda.Ru

Exclusion of Sir2 gene to extend human lifespan 6 times

Human beings are created to be immortal. It's hard to deny that everybody wants to believe in it. And everybody believes. This kind of self-love among biological species is not unusual and one should not be ashamed of it because evolution is too slow to raise any feelings and that's why humans are hiding from epochs falling in love with themselves.

It's been well established with previous research that an extra copy of the SIR2 gene can promote longevity in yeast, worms and fruit flies. But a counterintuitive experiment that deleted the gene entirely has resulted in one of the longest recorded life-span extensions in any organism. The new study, by scientists at the University of Southern California, suggests that SIR2 promotes, rather than retards, aging. The findings may throw a spanner into the works of biotech companies and their anti-aging drug development programs, according to scienceagogo.com

"When you do this genetic manipulation, you can get some of the longest lifespans ever described," said Valter Longo, a biomedical gerontologist at the University of Southern California. "We have good reason to believe this genetic effect is conserved in other organisms. We're working with mice and human cells now and are already starting to see the same response," reports Guardian

The study, "Sir2 Blocks Extreme Life-Span Extension," appears in the Nov. 18 edition of the biology journal Cell. The lead author is Valter Longo, assistant professor in the Leonard Davis School of Gerontology and the USC College of Letters, Arts and Sciences. I.L.

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