The film, "State of Play," was to star Pitt as a political consultant-turned-journalist who helps investigate the death of a congressman's mistress.
He left the production Wednesday, Hollywood trade paper Daily Variety reported on its Web site.
"Brad Pitt has left the Universal Pictures production of 'State of Play,"' the studio said in a statement. "We remain committed to this project and to the filmmakers, cast members, crew and others who are also involved in making the movie. We reserve all rights in this matter."
A message left early Friday for Pitt's publicist, Cindy Guagenti, was not immediately returned.
Putin's official spokesman Dmitry Peskov commented on remarks in the US media about failures in launching nuclear-capable missiles in Russia
More than 5.8 million people voted for Nicholas Maduro at the presidential election in Venezuela. This is more than a quarter of registered voters. Why did those people vote for the man, who, as Western media write, took Venezuela to the brink of collapse?
It has long been understood that the West has been trying to subject Russian borders to total control. We have not seen such activity even during the Cold War