"The Prince of Darkness" was invited to perform at the annual Royal Variety Performance in Cardiff, Wales, on Nov. 21, said Osbourne's spokesman Lathum Nelson.
Osbourne, 56, will join an international slate of entertainers that includes Italian tenor Andrea Bocelli and New York's Blue Man Group. His wife, Sharon, will also participate in the program.
This is the second time Osbourne has been invited to participate in the Royal Variety Performance. A scheduling conflict preventing him from attending last year, Osbourne said in a statement.
Osbourne, whose latest album, "Under Cover," was released Nov. 1, had been scheduled to appear at the Video Game Awards in Los Angeles on Nov. 18, AP reports.