Tottenham, three-times winners of the competition, suffered a humiliating 1-0 defeat by League Two Grimsby in the League Cup second round on Tuesday.
Democratic Republic of Congo striker Jean-Paul Kamudimba Kalala was Grimsby's hero in the 89th minute, lashing the ball into the net from just outside the area.
Birmingham were the night's other Premiership losers, going down 3-2 at Gillingham after extra time while Aston Villa came from 3-1 down to win 8-3 at Wycombe.
Villa, five-times League Cup winners, scored seven goals in the second half, Gareth Barry and James Milner claiming two each.
West Ham won 4-2 at Sheffield Wednesday, Charlton beat Hartlepool 3-1, Finland striker Mikael Forssell set Birmingham on the way to a 2-0 victory at Scunthorpe United and West Brom crushed Bradford City 4-1.
The eight Premier League clubs who qualified for European competition, led by holders Chelsea, join the competition in the third round next month, CNN reports.
Russia may terminate all kinds of military and military-technical relations with Israel, including the agreement on the exchange of reconnaissance data
The Kremlin is very concerned about the events related to the crash of the Il-20 Russian military aircraft in Syria