Defending champion CSKA Moscow lost a UEFA Cup match for the first time in 11 games on Thursday to visiting Marseille 2-1.
AS Roma, Stuttgart, Hertha Berlin and Palermo also won during the first rotation of the UEFA Cup's group stage, while 2004 Champions League runner-up Monaco lost at Viking 1-0.
Sabri Lamouchi put Marseille in the lead with a header in the 23rd minute, connecting on a high pass to beat goalkeeper Igor Akinfeev. Fifteen minutes later, Mamadou Niang met Bostjan Cesar's cross from the right and scored from 13 meters.
CSKA substitute Vagner Love stretched his leg to meet Alexander Salugin's cross in the goal box to make it 2-1 in the 80th.
Marseille goalkeeper Fabien Barthez, who returned after a six-month ban for spitting at a referee, left the goal to intercept Sergei Samodin's attempt one-on-one in the 65th, and had another stunning save in the next minute, leaping to his right to stop Yevgeny Aldonin's drive from inside the box.
The last time Marseille and CSKA Moscow played, the French team won 6-0 and went on to win the 1993 Champions League title.
CSKA had not lost a UEFA Cup match since it dropped into the round of 32 in Europe's second-tier club competition from the Champions League last season. It won both its first round matches in the UEFA Cup this season.
CSKA became the first Russian club to win a European title when it beat Sporting Lisbon 3-1 in the UEFA Cup final in May. The Russian team is the only previous winner of the 40 teams still alive in the competition.
The top three teams from each of the eight five-team groups advance to the knockout round of 32. Each club plays four times, twice at home and twice away, with the schedule decided randomly.
Roma also won on the road, needing an 84th-minute strike from substitute Leandro Cufre for a 2-1 win over Norwegian side Tromso. Samuel Kuffour opened the scoring for Roma in the 35th minute, heading a corner past Tromso goalkeeper Lars Hirschfeld.
Ole Martin Aarst tied it six minutes later, beating 'keeper Donebier Marangon with a shot from five meters after Roma failed to clear the ball from a free kick. Roma's Simone Perrotta was red-carded in the 89th, after a tough tackle on Tromso's Stephan Ademolu.
Palermo also won on the road, beating Israel's Maccabi Petach-Tikva 2-1 in Group B. Palermo, which was in Italy's third division five years ago, got its winning goal from Christian Terlizzi in the 77th. Franco Brienza also scored for Palermo, while Omer Golan got one back for the host.
Toni Nhleko scored in the 18th minute for Viking, netting a rebound from a difficult angle to upset Monaco.
Hertha Berlin topped Halmstads BK 1-0, with Andreas Neuendorf scoring the only goal. Stuttgart received goals from Jon Dahl Tomasson and Danijel Ljuboja in a 2-0 win over Rennes.
Steaua Bucharest, the 1986 European champion, beat French club Lens 4-0 off goals from Victoras Iacob, Dorin Goian and two from Nicolae Dica. Lens striker Aruna Dindane was sent off in the 79th for two yellow cards.
Hamburg won 1-0 over CSKA Sofia through Rafael Van der Vaart's left-foot volley from 25 meters.
CSKA Sofia eliminated Germany's Bayer Leverkusen, the 1988 champion, in the first round.
Bolton drew 1-1 at Turkey's Besiktas with Jared Borgetti scoring the equalizer for the English team. Middlesbrough beat Swiss side Grasshoppers 1-0 with a goal from Jimmy Floyd Hasselbaink.
Also, it was: Shakhtar Donetsk 1, PAOK Thessaloniki 0; Zenit St. Petersburg 2, Guimaraes 1; Basel 0, Strasbourg 2; Dnipro Dnipropetrovsk 1, AZ Alkmaar 2; and Dinamo Bucharest 0, Heerenveen 0, AP reports.