Antonenko pulled away around the 11-kilometer (7-mile) mark and was never challenged. His time of 2 hours, 13 minutes, 54 seconds was more than 6 minutes faster than second-place Joseph Mutinda.
Antonenko placed second in the Twin Cities Marathon in 2004, finishing behind Augustus Kavutu Mbusya, who was third Sunday.
Ponomarenko won in her first marathon after running neck and neck with Sharon Cherop for much of the route. Her winning time was 2:34:09.