The 7.2 magnitude earthquake could be felt as far as Delhi and the Gulf, but Pakistani officials said there were no immediate reports of casualties.
The United States' Geological Survey said the epicentre was around 30 miles west of Dalbandin at a depth of about 50 miles, according to Telegraph.co.uk.
Arif Mahmood, director of the Pakistan Meteorological Department, put the epicenter at 320 kilometers (about 200 miles) southwest of Quetta near Kharan, Balochistan, and said it had been felt in Punjab, Sindh, and Balochistan provinces in Pakistan, as well as parts of Iran and India.
Mahmood predicted major aftershocks. "Earthquakes with such magnitudes in the past have brought on aftershocks," he told from Islamabad, CNN reports.
Government officials warned Pakistan will live with the danger of possible aftershocks in coming days. In some instances such aftershocks have come within a week of previous earthquakes.
In Karachi, Saeeda Jehan, a middle aged woman and mother of six children, quietly read religious verses from an Islamic prayer book she carried as she waited for the building with her apartment to be declared safe for her return.
"I was watching TV when suddenly the TV screen began shaking. Then I realized it was a very strong earthquake," Jehan told CBS News while standing in a crowd at Karachi's Stargate neighborhood near the city's main airport, CBS NEWS informs.