Source Pravda.Ru

Diabetes pill can double risk of death, study says

A new diabetes pill that appeared headed for federal approval can double the risk for deaths, heart attacks and strokes, according to a study released online Thursday because of public safety concerns.

The drug muraglitazar, developed by Bristol-Myers Squibb and Merck & Co. under the brand name Pargluva, was endorsed by a Food and Drug Administration panel last month. It is a treatment for Type 2 diabetes, the most common form of the condition that occurs most often in adults who are overweight.

But Cleveland Clinic researchers who analyzed data the FDA made public before the panel vote found that patients taking Pargluva faced double the risk of death, heart attack or stroke, compared with those on dummy pills or a similar drug.

The drug's makers said earlier this week that they had received an "approvable" letter from the FDA that also asked for more safety data on the drug's cardiovascular effects.

"It is beyond me why individuals who are supposed to be overseeing the safety of the public would take a chance when it's not necessary," said Dr. Catherine DeAngelis, JAMA's editor in chief. "It's not like there are not other drugs that can be used" for diabetes.

The non-insulin drug is designed to lower blood sugar levels and increase levels of "good" cholesterol in patients with Type 2 diabetes, the AP reports.

DeAngelis said the Cleveland Clinic analysis shows much more study is needed, and she likened the situation to what occurred with Merck's Vioxx. Merck removed the painkiller from the market last year because of evidence linking it with cardiac problems. Critics contend the FDA did not adequately address safety concerns raised about Vioxx. A.M.

Comments
Africa's heart bleeds, who is to blame?
Woman sucks her men dry in bed like female spider
China wages trade war against US, remains largest investor in US debt
Russia mourns victims of Ilyushin Il-20 shootdown
How Russia can respond to Israel following Ilyushin Il20 shootdown
How Russia can respond to Israel following Ilyushin Il20 shootdown
Russia mourns victims of Ilyushin Il-20 shootdown
NATO's 5,000 warplanes ready to bomb Russia, Chinese media say
Ukraine's Poroshenko signs decree to terminate Treaty of Friendship with Russia
Ukraine's Poroshenko signs decree to terminate Treaty of Friendship with Russia
Putin speaks about God and warns Ukraine
Putin speaks about God and warns Ukraine
How Russia can respond to Israel following Ilyushin Il20 shootdown
Russia obediently sells RD-180 rocket engines to USA if and when requested
Russia obediently sells RD-180 rocket engines to USA if and when requested
Russia mourns victims of Ilyushin Il-20 shootdown
53 million Russians may lose their jobs within a few years
How Russia can respond to Israel following Ilyushin Il20 shootdown
MiG-31 supersonic fighter jet crashes in Central Russia, pilots eject
MiG-31 supersonic fighter jet crashes in Central Russia, pilots eject
MiG-31 supersonic fighter jet crashes in Central Russia, pilots eject